Table 3. Top 10 up- and down-regulated genes in response to in vitro stimulation of chicken thrombocyte.
| ENSGALG ID | Gene | Transcript Name | logFc• | Known or possible function |
|---|---|---|---|---|
| ENSGALG00000010915 | IL6 | Interleukin 6 | 9.63 | Inflammatory response and b cell maturation |
| ENSGALG00000026420 | CSF3 | Colony Stimulating Factor 3 | 9.31 | Cytokine that controls various aspects of granulocyte production |
| ENSGALG00000005616 | ARSI | Arylsulfatase Family, Member | 7.49 | Hormone biosynthesis, cell signaling |
| ENSGALG00000011668 | K60/ IL8L1 | Interleukin-8 precursor/ interleukin 8-like 1 | 7.25 | |
| ENSGALG00000005619 | F3 | Coagulation Factor III | 7.12 | Cell surface glycoprotein, affinity receptor for F7 |
| ENSGALG00000026098 | IL8 | Interleukin-8 | 6.74 | Mediates activation and migration of neutrophils |
| ENSGALG00000006106 | TNFRSF6B | Tumor Necrosis Factor Receptor Superfamily, Member 6b | 6.58 | Suppression of cell death |
| ENSGALG00000000534 | IL1B | Interleukin 1, Beta | 6.54 | Induction of COX2, mediator of the inflammatory response |
| ENSGALG00000021025 | LOC419276 | Bactericidal permeability-increasing protein-like | 5.95 | Antibacterial response |
| ENSGALG00000016919 | IRG1 | Immunoresponsive 1 Homolog | 5.95 | Negative regulator of TLR mediated responses |
| ENSGALG00000012061 | GPD1 | Glycerol-3-phosphate dehydrogenase | -7.38 | a component of glycerophospholipids. |
| ENSGALG00000004827 | Uncharacterized | -6.63 | ||
| ENSGALG00000017150 | ARHGAP20 | Rho GTPase Activating Protein 20 | -6.31 | related pathways are Signaling by GPCR and Signaling by Rho GTPases. |
| ENSGALG00000001171 | SEMA68 | Semaphorin VIB | -6.02 | may be involved in both peripheral and central nervous system development |
| ENSGALG00000001527 | VWA1 | Von Willebrand Factor A Domain Containing 1 | -5.82 | appears to play a role in cartilage structure and function |
| ENSGALG00000024466 | CC17 | Uncharacterized protein | -5.13 | |
| ENSGALG00000009589 | GAD67 | Glutamate Decarboxylase 1 (Brain, 67kDa) | -4.95 | responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid |
| ENSGALG00000010903 | RASGEF1B | RasGEF Domain Family, Member 1B | -4.18 | Guanine nucleotide exchange factor |
| ENSGALG00000028373 | GAS2L3 | Growth Arrest-Specific 2 Like 3 | -4.02 | Cytoskeletal linker protein |
| ENSGALG00000007114 | APOA1 | Apolipoprotein A-I | -3.85 | Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase |
*(logFC indicates the log2 of the fold-change between the treated and untreated samples)