Table 2. Percentage of JAK/STAT family positivity (in grey)/negativity in dermal inflammatory cells of ISDs comparing to controls.
| Controls | Pso | LP | CLE | AD | AA | PG | ||
|---|---|---|---|---|---|---|---|---|
| JAK1 | Positive(%) | 26(4/15) | 64(9/14) | 61*(13/21) | 50(10/20) | 50(10/20) | 42(3/7) | 80*(8/10) |
| Negative(%) | 74(11/15) | 36(5/14) | 29(8/21) | 50(10/20) | 50(10/20) | 68(4/7) | 20(2/10) | |
| pJAK1 | Positive(%) | 43.75(7/16) | 94,7*(18/19) | 85,71*(18/21) | 100*(20/20) | 95*(19/20) | 71.4(5/7) | 100*(10/10) |
| Negative(%) | 56.25(9/16) | 5.26%(1/19) | 14.29(3/21) | 0 | 5(1/20) | 28.6(2/7) | 0 | |
| JAK2 | Positive(%) | 100(18/18) | 100(20/20) | 100(10/10) | 100(10/10) | 100(10/10) | 85(6/7) | 100(10/10) |
| Negative(%) | 0 | 0 | 0 | 0 | 0 | 15(1/7) | 0 | |
| pJAK2 | Positive(%) | 47(8/17) | 58.8(10/17) | 80(8/10) | 60(6/10) | 90*(9/10) | 71(5/7) | 100*(10/10) |
| Negative(%) | 53(9/17) | 41.2(7/107) | 20(2/10) | 40(4/10) | 10 (01/10) | 29(2/7) | 0 | |
| JAK3 | Positive(%) | 11(2/18) | 13(2/15) | 10(1/10) | 40(4/10) | 70*(7/10) | 14.3(1/7) | 90*(9/10) |
| Negative(%) | 89(16/18) | 87(13/15) | 90(9/10) | 60(6/10) | 30(3/10) | 85.7(6/7) | 10(1/10) | |
| pJAK3 | Positive(%) | 5,56(1/18) | 52,63*(10/19) | 70*(7/10) | 20(2/10) | 80*(9/10) | 71.4*(5/7) | 80*(8/10) |
| Negative(%) | 94,44(17/18) | 47,37(9/19) | 30(3/10) | 80(8/10) | 20(1/10) | 28.6(2/7) | 20(2/10) | |
| TYK2 | Positive(%) | 100(17/17) | 100(19/19) | 20*(2/10) | 100(10/10) | 100(10/10) | 100(7/7) | 100(10/10) |
| Negative(%) | 0 | 0 | 80(8/10) | 0 | 0 | 0 | 0 | |
| pTYK2 | Positive(%) | 94(17/18) | 83(15/18) | 100(10/10) | 90(9/10) | 100(10/10) | 100(7/7) | 100(10/10) |
| 6(1/18) | 17(3/18) | 0 | 10(1/10) | 0 | 0 | 0 | ||
| pSTAT1 | Positive(%) | 12,5(2/16) | 41(7/17) | 59*(13/22) | 84.2*(16/19) | 50*(10/20) | 0 | 80*(8/10) |
| Negative(%) | 87.5(14/16) | 59(10/17) | 41(9/22) | 15.8(3/19) | 50(10/20) | 100(7/7) | 20(2/10) | |
| pSTAT2 | Positive(%) | 29.4(5/17) | 55(10/18) | 47.6(11/21) | 0 | 85*(17/20) | 71(5/7) | 100*(10/10) |
| Negative(%) | 70.6(12/17) | 45(8/18) | 52.4(10/21) | 100(20/20) | 15(3/20) | 29(2/7) | 0 | |
| pSTAT3 | Positive(%) | 43.7(7/16) | 62.5(10/16) | 50(10/20) | 65(13/20) | 80*(16/20) | 14.2(1/7) | 40(4/10) |
| Negative(%) | 56,3(9/16) | 37.5(6/16) | 50(10/20) | 35(7/20) | 20(4/20) | 85.8(6/7) | 60(6/10) |
Pso = psoriasis, LP = lichen planus, CLE = cutaneous lupus erythematosus, AD = atopic dermatitis, AA = alopecia areata, PG = pyoderma gangrenosum,
* = significant expression.