Table 2. Pharmacokinetic Profile of Compound 6j in Micea and Ratsb.
| mice |
rats |
|||
|---|---|---|---|---|
| oral 4 mg/kg | iv 1 mg/kg | oral 20 mg/kg | iv 4 mg/kg | |
| AUC(0–∞) (ng/mL·h) | 2554.1 | 1211.9 | 788.3 ± 41.5 | 236.0 ± 53.1 |
| T1/2 (h) | 1.1 | 0.2 | 1.3 ± 0 | 1.5 ± 0.3 |
| Tmax (h) | 0.5 | 1 ± 0 | ||
| Cmax (ng/mL) | 2193.9 | 2246.8 | 341.7 ± 115.5 | 473.3 ± 114.7 |
| CLz (L/h/kg) | 0.8 | 17.6 ± 4.4 | ||
| BA (%) | 41.6 | 66.8 | ||
a
ICR mice (male, 24 animals per group) weighing 18–30 g were used for the study.
b
SD rats (male, 3 animals per group) weighing 180–220 g were used for the study.