Figure 1.

Effect of HTLV-1 Tax varients on the E2-induced BRCA1-Luc and ERE-Luc expression. MCF-7 were co-transfected with either a plasmid expessing BRCA1-Luc (1.5 μg) (A) or ERE-Luc (1.5 μg) (B) alone or together with the indicated combinations of Tax varients (M22, M47 and M89A) expressing plasmids without (left lane) or with (right lane) E2 treatment. The E2 was added to the cultures 5 hr before harvesting the cells for analyzing the reporter expression. The presented results are an average of 3 repeated experiments ± SE.