Figure 2.

Effect of CBP/p300 and cyclin T1 on E2- ERα transcriptional activities with or without Tax. MCF-7 were co-transfected with either a plasmid expessing BRCA1-Luc (A) or ERE-Luc (B) alone or with the indicated combinations of w.t.Tax, CBP/ p300, cyclineT1, HEXIMI expressing plasmids without (left lane) or with (right lane) E2 treatment. The E2 was added to the cultures 5 hr before harvesting the cells for analyzing the reporter expression. The presented results are an average of 3 repeated experiments ± SE.