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. 2016 Jun 13;15(19):2593–2607. doi: 10.1080/15384101.2016.1198862

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© 2016 The Author(s). Published with license by Taylor & Francis.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 3. — Real GECNs of HeLa and ES cells. The number of G1 and S phase TFs and genes, and G2 phase TFs decreased significantly in HeLa compared to that in ES cells; whereas the number of M phase TFs and genes increased significantly. In addition, the numbers of G1, S, and G2 phase TF regulations in HeLa cells also decreased compared to ES cells; whereas the number of M phase TF regulations increased. These results support the immortal nature of HeLa cells being due to dysregulation of genes at the G1/G2 checkpoint and cell cycle exit.