Table 2.

Proposed multiple drugs for the treatment of cervical cancer.Proposed targets and structures of methotrexate, quercetin, and mimosine derived from the ZINC database. The identified drugs suppress activated cell cycle genes, such as ARID5B, STK17B, and CCL2, without affecting 6 common core genes, PLK1, TOP2A, AURKB, FAM83D, HJURP, and HMMR. The ranked list of all drugs in CMap is shown in Table S5. Methotrexate targets abnormal methylation in S phase, quercetin inhibits anti-apoptosis in G2 phase, and mimosine blocks most signal transduction and inhibits anti-apoptosis in S phase. Apoptosis reduces accumulated genetic mutations, abnormal DNA methylations, and the dysregulation of miRNAs in normal cells; thus, achieving carcinogenesis inhibition.

Drug molecule	Cell cycle gene (PGNP projection value)
Methotrexate	ARID5B (2.742993)
Quercetin	STK17B (0.210057)
Mimosine	CCL2 (0.013344)