Table 1. Biopterin distribution in organs after 6RBH4 administration.
| 0-time | 30 min | 120 min | ||||||
|---|---|---|---|---|---|---|---|---|
| organ weight (g) | relative1)to body | BP (nmol) | relative2)to liver | BP (nmol) | relative3)to dose | BP (nmol) | relative3)to dose | |
| Liver | 6.9 | 2.8% | 40.4 | (100%) | 367 | 7.1% | 268 | 5.2% |
| Blood | 17 | 6.8% | 8.32 | 21% | 76.8 | 1.5% | 39.5 | 0.76% |
| Kidneys | 1.8 | 0.72% | 1.22 | 3.0% | 70.6 | 1.4% | 17.3 | 0.3% |
| Brain | 1.5 | 0.60% | 0.62 | 1.5% | 0.8 | 0.15% | 0.71 | 0.14% |
| Sub-total | 27 | 11% | 50.6 | n.a. | 515 | 9.9% | 325 | 6.3% |
Biopterin distribution in liver compared with the other organs. Data apply to Figs 3 and 4. BP contents (nmol/organ) are expressed as the mean values and are multiplied by the respective organ weights (g).
1) Relative to a 250 g body weight, adapted from “SD-Rat Control Data 2009” of Charles River Laboratories Japan, Inc.
2) Relative to the amount of BP in whole liver (nmol)
3) Relative to dose: (increase in organ BP over 0-time) / (5180 nmol: 6RBH4 dose per 250 g).