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. 2016 Oct 6;11(10):e0163629. doi: 10.1371/journal.pone.0163629

Fig 6. Bioinformatic analysis of osteogenic biomarker gene product interactions.

Fig 6

STRING (v9.05) software confidence view, with stronger associations represented by thicker lines, for (A) the osteogenic biomarkers not common to all osteogenic functional phenotypes, constituted a disconnected network. The software predicted three closest functional partners (highlighted acronym) and relative scores were: type I collagen alpha 2 (COL1A2; 0.999); MKI67 interacting nucleolar phosphoprotein (MKI67IP; 0.996) and integrin alpha 2/CD49b; 0.987). (B) the osteogenic signature gene biomarkers common to all osteogenic functional ex vivo and in vivo phenotypes constituted a closely connected network. The software predicted three closest functional partners (highlighted) and relative scores were: type I collagen alpha 1 (COL1A1; 0.999); Transforming growth factor, beta 1 (TGFB1; 0.999); and type III collagen alpha 1 (COL3A1; 0.993).