Table 1. Characterisation of donor-specific cGMP-hBM-MSC population.
Donor | Gender | Age | CFU-F | CD34+ | CD45+ | CD73+ | CD90+ | CD105+ | HLA-DR, DP, DQ+ |
---|---|---|---|---|---|---|---|---|---|
#1 | M | 54 | 196 | 0.02 | 1.94 | 99.90 | 96.9 | 99.72 | 1.28 |
#2 | F | 51 | 30 | ND | 0.97 | 100 | 100 | ND | 2.9 |
#3 | F | 24 | 550 | 0.10 | 0.14 | 97.43 | 99.81 | 98.5 | 2.58 |
#4 | M | 42 | 68 | 0.00 | 4.4 | 100 | 100 | 99.76 | 0.4 |
#5 | F | 24 | 92 | 0.17 | 0.07 | 98.82 | 99.69 | 99.56 | 2.85 |
#6 | M | 21 | 98 | 0.03 | 0.05 | 99.9 | 100 | 93.14 | 0.28 |
*The number of Colony forming Unit-Fibroblast per 106 mononuclear cells scored after the initial plating of the bone marrow sample. The % immunophenotype positivity was determined at passage 1 before shipment. CD34, Hematopoietic Progenitor Cell Antigen CD34; CD45, leukocyte common antigen; CD73, Ecto-5'-nucleotidase; CD90, Thymocyte antigen 1; CD105, Endoglin; HLA-DR, DP, DQ, Human leukocyte antigens. ND: not determined.