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. 2016 Apr 20;7(19):26992–27006. doi: 10.18632/oncotarget.8853

Figure 6. Dysregulation of peritoneal cavity B1a cells of p40−/−IL-2Rα−/− mice under inflammatory scenario.

Figure 6

On the one hand, some molecules with ITIM domains like BTLA, CD72 and CD22, were significantly increased to inhibit BCR signaling transduction. Meanwhile, the B1a cell cycle was delayed as the expression of Ki67 and other cell cycle related genes were decreased, leading to the reduced number of B1a cells. On the other hand, some regulatory molecules, e.g. IL-10, were significant decreased because of the up-regulation of Ahr. Consequently, the regulatory function of B1a cells was impaired, leading to the augmentation of IFN-γ secretion form T cells.