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. 2016 Mar 17;7(19):27067–27084. doi: 10.18632/oncotarget.8166

Figure 2. Coupling of core EMT circuit (miR-200/ZEB driven by SNAIL) with other ‘phenotypic stability factors’ (PSFs).

Figure 2

A. OVOL forms a mutually inhibitory loop with ZEB, inhibits miR-200, and self-inhibits. B. GRHL2 forms a mutually inhibitory loop with ZEB. C. miR-145 and OCT4 mutually inhibit each other, miR-145 and ZEB also form a double negative loop, and OCT4 activates miR-200. Solid lines represent transcriptional regulation, while dotted lines represent miRNA-mediated regulation; arrows denote activation, bars for inhibition. Details of coupling for these PSFs with miR-200/ZEB are in SI section 1.