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| Gene | cDNA mutation | Impact on protein synthesis | Primary tumors occurence (N) | Metastases occurence (N) |
|---|---|---|---|---|
| PIK3CA | C1616G | P539R | 1 | 1 |
| G1624A | E542K | 1 | 1 | |
| G1633A | E545K | 3 | 2 | |
| A3140G | H1047R | 4 | 4 | |
| A3140T | H1047L | 2 | 2 | |
| G353A | G118D | 1 | 1 | |
| TP53 | C152G | S51X* | 1 | 1 |
| G128A | R43H | 1 | 1 | |
| G317A | C106Y | 1 | 1 | |
| T304C | Y102H | 1 | 1 | |
| C421T | R141C | 0 | 1 | |
| G422T | R141L | 1 | 1 | |
| AKT1 | G49A | E17K | 2 | 2 |
| ERBB2 | T2264C | L755S | 0 | 1 |
| Total | 19 | 20 | ||
Stop codon
