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. 2016 Mar 29;7(19):27255–27266. doi: 10.18632/oncotarget.8463

Table 1. Patient characteristics.

N 203
Patient sex
 Male 116 (57%)
 Female 87 (43%)
Median patient age, years (range) 58 (21-73)
AML cytogenetic risk
 Favorable 4 (2%)
 Intermediate 142 (70%)
 Adverse 42 (21%)
 Failed 15 (7%)
Number of induction courses to achieve CR1
 1 133 (66%)
 >1 70 (34%)
Interval from diagnosis to achieve CR1, days (range) 51 (21-350)
Interval from CR1 to transplantation, days (range) 115 (15-351)
Median donor age, years (range) 34 (19-61)
Donor sex
 Male 135 (67%)
 Female 68 (33%)
Female donor to male recipient 32 (16%)
Patient CMV serosatus
 Negative 94 (46%)
 Positive 109 (54%)
Donor CMV serostatus
 Negative 134 (66%)
 Positive 69 (34%)
Conditioning
 Chemotherapy-based 143 (70%)
  Fludarabine + busulfan 110
  Fludarabine + treosulfan 14
  Fludarabine + melphalan 12
  Other 7
 TBI-based 60 (30%)
In-vivo T-cell depletion 166 (82%)
 ATG 153
 Campath 13
GVHD prophylaxis
 CsA + Mtx 129 (64%)
 CsA + MMF 69 (34%)
 Other 5 (2%)
Median CD34(+) dose, cells per kilogram x 10^6 (range) 6.53 (1.34-41.3)
 Interquartile range 5.0-8.25
Median CD3(+) dose, cells per kilogram x 10^6 (range) 250 (50-885)
 Interquartile range 175.4-347
Median year of transplantation, range 2011 (2000-2012)
Median follow-up, months (range) 22 (3-105)

Abbreviations: AML – acute myeloid leukemia; CR1 – first complete remission; CMV – cytomegalovirus; TBI - total body irradiation; ATG - antithymocyte globulin; GVHD – graft-versus-host disease; CsA – cyclospirin A; Mtx – methotrexate; MMF - mycophenolate mofetil