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. 2016 Mar 30;7(19):27408–27421. doi: 10.18632/oncotarget.8478

Figure 5. Systemic injection of AdASK1 suppresses orthotopic hepatocellular carcinoma growth.

Figure 5

(A) Images (left) and statistical analysis (right) of luciferase signals of the experiment in BALB/c nude mice transplanted with Huh7 cells stably expressing luciferase. An orthotopic HCC model was established based on implantation of Huh7 tumor piece into the liver, and then AdASK1 or AdRFP injection through tail vein (n = 8 in each group). (B) Images of tumor nodules with systemically injected AdASK1 or AdRFP at the endpoint. (C) Tumor weight measured at the endpoint. (D) RT-PCR analysis of ASK1 mRNA expression in tumor nodules systemically injected with AdASK1 or AdRFP. (E) Representative images of H & E stained, Ki67 immunohistochemistry and tunel stained of serial sections from tumor nodules systemically injected with AdASK1 or AdRFP. Magnification, ×100, ×200, ×400 and ×1260; Horizontal lines in A, C, and D indicate the median value.