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. 2016 Mar 30;7(19):27665–27675. doi: 10.18632/oncotarget.8491

Table 1. Genotype frequencies of PSCA polymorphisms in cases and controls.

Model Genotype Cases (n,%) Control (n,%) P OR (95% CI)
rs2294008 HWE: P=0.195
Co-dominant CC 273 (48.8%) 299 (51.3%)
Heterozygote TC 231 (41.3%) 247 (42.4%) 0.85 1.02 (0.80-1.31)
Homozygote TT 56 (10.0%) 37 (6.3%) 0.03 1.67 (1.06-2.59)
Dominant CC 273 (48.8%) 299 (51.3%)
TC+TT 287 (51.3%) 284 (48.7%) 0.39 1.11 (0.88-1.40)
Recessive CC+TC 504 (90.0%) 546 (93.7%)
TT 56 (10.0%) 37 (6.3%) 0.02 1.64 (1.06-2.53)
Overdominant CC+TT 329 (%) 336 (57.6%)
TC 231 (%) 247 (42.4%) 0.70 0.96 (0.76-1.21)
Allele C 777(69.4%) 845 (72.5%)
T 343(30.6%) 321 (27.5%) 0.10 1.16 (0.97-1.39)
rs2976392 HWE: P=0.164
Co-dominant GG 287 (51.3%) 298 (51.1%)
Heterozygote GA 230 (41.1%) 247 (42.4%) 0.79 0.97 (0.76-1.23)
Homozygote AA 43 (7.7%) 38 (6.5%) 0.50 1.18 (0.74-1.87)
Dominant GG 287 (51.3%) 298 (51.1%)
GA+AA 273 (48.8%) 285 (48.9%) 0.96 1.00 (0.79-1.25)
Recessive GG+GA 517 (92.3%) 545 (93.5%)
AA 43 (7.7%) 38 (6.5%) 0.45 1.19 (0.76-1.88)
Overdominant GG+AA 330 (58.9%) 336 (57.6%)
GA 230 (41.1%) 247 (42.4%) 0.66 0.95 (0.75-1.20)
Allele G 804 (71.8%) 843 (72.3%)
A 316 (28.2%) 323 (27.7%) 0.79 1.03 (0.85-1.23)
rs2978974* HWE: P=0.179
Co-dominant GG 254 (45.4%) 283 (48.5%)
Heterozygote GA 259 (46.3%) 256 (43.9%) 0.33 1.13 (0.89-1.44)
Homozygote AA 46 (8.2%) 44 (7.5%) 0.50 1.17 (0.75-1.82)
Dominant GG 254 (45.4%) 283 (48.5%)
GA+AA 305 (54.6%) 300 (51.5%) 0.29 1.13 (0.90-1.43)
Recessive GG+GA 513 (91.8%) 539 (92.5%)
AA 46 (8.2%) 44 (7.5%) 0.67 1.10 (0.71-1.69)
Overdominant GG+AA 300 (53.7%) 327 (56.1%)
GA 259 (46.3%) 256 (43.9%) 0.41 1.10 (0.87-1.39)
Allele G 767(68.6%) 822 (70.5%)
A 351(31.4%) 344 (29.0%) 0.33 1.09 (0.92-1.31)

OR: odds ratio; 95%CI: confidence interval.

*

Cases of rs2978974 polymorphism missing n = 1

Adjusted for age and body mass index.