Table 1. Genotype frequencies of PSCA polymorphisms in cases and controls.
Model | Genotype | Cases (n,%) | Control (n,%) | P† | OR (95% CI) |
---|---|---|---|---|---|
rs2294008 | HWE: P=0.195 | ||||
Co-dominant | CC | 273 (48.8%) | 299 (51.3%) | ||
Heterozygote | TC | 231 (41.3%) | 247 (42.4%) | 0.85 | 1.02 (0.80-1.31) |
Homozygote | TT | 56 (10.0%) | 37 (6.3%) | 0.03 | 1.67 (1.06-2.59) |
Dominant | CC | 273 (48.8%) | 299 (51.3%) | ||
TC+TT | 287 (51.3%) | 284 (48.7%) | 0.39 | 1.11 (0.88-1.40) | |
Recessive | CC+TC | 504 (90.0%) | 546 (93.7%) | ||
TT | 56 (10.0%) | 37 (6.3%) | 0.02 | 1.64 (1.06-2.53) | |
Overdominant | CC+TT | 329 (%) | 336 (57.6%) | ||
TC | 231 (%) | 247 (42.4%) | 0.70 | 0.96 (0.76-1.21) | |
Allele | C | 777(69.4%) | 845 (72.5%) | ||
T | 343(30.6%) | 321 (27.5%) | 0.10 | 1.16 (0.97-1.39) | |
rs2976392 | HWE: P=0.164 | ||||
Co-dominant | GG | 287 (51.3%) | 298 (51.1%) | ||
Heterozygote | GA | 230 (41.1%) | 247 (42.4%) | 0.79 | 0.97 (0.76-1.23) |
Homozygote | AA | 43 (7.7%) | 38 (6.5%) | 0.50 | 1.18 (0.74-1.87) |
Dominant | GG | 287 (51.3%) | 298 (51.1%) | ||
GA+AA | 273 (48.8%) | 285 (48.9%) | 0.96 | 1.00 (0.79-1.25) | |
Recessive | GG+GA | 517 (92.3%) | 545 (93.5%) | ||
AA | 43 (7.7%) | 38 (6.5%) | 0.45 | 1.19 (0.76-1.88) | |
Overdominant | GG+AA | 330 (58.9%) | 336 (57.6%) | ||
GA | 230 (41.1%) | 247 (42.4%) | 0.66 | 0.95 (0.75-1.20) | |
Allele | G | 804 (71.8%) | 843 (72.3%) | ||
A | 316 (28.2%) | 323 (27.7%) | 0.79 | 1.03 (0.85-1.23) | |
rs2978974* | HWE: P=0.179 | ||||
Co-dominant | GG | 254 (45.4%) | 283 (48.5%) | ||
Heterozygote | GA | 259 (46.3%) | 256 (43.9%) | 0.33 | 1.13 (0.89-1.44) |
Homozygote | AA | 46 (8.2%) | 44 (7.5%) | 0.50 | 1.17 (0.75-1.82) |
Dominant | GG | 254 (45.4%) | 283 (48.5%) | ||
GA+AA | 305 (54.6%) | 300 (51.5%) | 0.29 | 1.13 (0.90-1.43) | |
Recessive | GG+GA | 513 (91.8%) | 539 (92.5%) | ||
AA | 46 (8.2%) | 44 (7.5%) | 0.67 | 1.10 (0.71-1.69) | |
Overdominant | GG+AA | 300 (53.7%) | 327 (56.1%) | ||
GA | 259 (46.3%) | 256 (43.9%) | 0.41 | 1.10 (0.87-1.39) | |
Allele | G | 767(68.6%) | 822 (70.5%) | ||
A | 351(31.4%) | 344 (29.0%) | 0.33 | 1.09 (0.92-1.31) |
OR: odds ratio; 95%CI: confidence interval.
Cases of rs2978974 polymorphism missing n = 1
Adjusted for age and body mass index.