Table 2. Association between PSCA SNPs and age of breast cancer patients.
Age(years) | genotype distributions(case/control) | Co-dominant | Dominant | Recessive | Allele | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
AA | Aa | aa | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | |
rs2294008 | |||||||||||
<49 | 135/157 | 128/131 | 31/23 | 0.46m 0.13n |
1.14(0.81-1.59)m 1.57(0.87-2.82)n |
0.26 | 1.20 (0.87-1.65) | 0.18 | 1.48 (0.84-2.60) | 0.15 | 1.20 (0.94-1.53) |
≥49 | 138/142 | 103/116 | 25/14 | 0.62m 0.08n |
0.91(0.64-1.30)m 1.84(0.92-3.68)n |
0.94 | 1.01 (0.72-1.42) | 0.06 | 1.91 (0.97-3.76) | 0.40 | 1.12 (0.86-1.47) |
rs2976392 | |||||||||||
<49 | 156/163 | 117/130 | 21/18 | 0.72m 0.56n |
0.94(0.67-1.31)m 1.22(0.63-2.37)n |
0.87 | 0.97 (0.71-1.34) | 0.50 | 1.25 (0.65-2.40) | 0.89 | 1.02 (0.79-1.31) |
≥49 | 131/135 | 113/117 | 22/20 | 0.98m 0.71n |
1.00(0.70-1.42)m 1.13(0.59-2.18)n |
0.93 | 1.02 (0.72-1.42) | 0.90 | 0.98 (0.70-1.38) | 0.81 | 1.03 (0.79-1.34) |
rs2978974 | |||||||||||
<49 | 135/159 | 142/138 | 17/14 | 0.25m 0.34n |
1.21(0.87-1.68)m 1.43(0.68-3.01)n |
0.20 | 1.23 (0.90-1.70) | 0.48 | 1.30 (0.63-2.69) | 0.21 | 1.17 (0.91-1.51) |
≥49 | 119/124 | 117/118 | 29/30 | 0.86m 0.98n |
1.03(0.72-1.48)m 1.01(0.57-1.78)n |
0.87 | 1.03 (0.73-1.44) | 0.98 | 1.00 (0.58-1.70) | 0.92 | 1.01 (0.79-1.31) |
A: Major allele; a: Minor allele;
m= Heterozygote model;
n= Homozygote model; OR: odds ratio; 95%CI: confidence interval.