Table 2. Comparison of tumor responses according to the RECIST (RECIST 1.0, RECIST 1.1, and modified RECIST 1.1) and PERCIST criteria.
| Tumor response by RECIST | Tumor response by PERCIST | Total | |||
|---|---|---|---|---|---|
| CMR | PMR | SMD | PMD | ||
| CR | 5 | 0 | 0 | 0 | 5 |
| PR | 21 | 60 | 5 | 0 | 86 |
| SD | 5 | 49 | 46 | 11 | 111 |
| PD | 1 | 4 | 5 | 56 | 66 |
| Total | 32 | 113 | 56 | 67 | 268 |
Abbreviations: CMR, complete metabolic response; CR, complete response; PMD, progressive metabolic disease; PD, progressive disease; PERCIST, PET Response Criteria in Solid Tumors; PMR, partial metabolic response; PR, partial response; RECIST, Response Evaluation Criteria in Solid Tumors; SD, stable disease; SMD, stable metabolic disease.
The level of concordance of tumor responses between the RECIST and PERCIST 1.0 is 0.590 (liner weighted k, with 95% confidence interval, 0.523-0.657).
The overall response rates were significantly different between two criteria (35.1% by the RECIST vs. 54.1% by the PERCIST, P < 0.0001).