Table 4. Influence of clinical characteristics on read-through transcript levels in lung adenocarcinoma tissue versus non-involved lung tissue, determined by testing in a multivariate linear model, using disease stage, smoking habit and sex as covariates.
| Read-through1 | Variable/Covariate2 | Coefficient estimate | SE3 | P4 |
|---|---|---|---|---|
| CHIA-PIFO | ||||
| Tissue | −11.88 | 4.85 | 0.0184 | |
| ELAVL-TIMM44 | ||||
| Tissue | −13.58 | 4.44 | 0.004 | |
| FAM162B-ZUFSP | ||||
| Tissue | −18.69 | 1.87 | 1.45 × 10−10 | |
| Sex | −4.982 | 2.00 | 0.019 | |
| Stage | 6.945 | 1.96 | 0.001 | |
| IFNAR2-IL10RB | ||||
| Tissue | −10.25 | 4.33 | 0.024 | |
| INMT-FAM188B | ||||
| Tissue | −20.33 | 3.65 | 2.43 × 10−6 | |
| KIAA1841-C2orf74 | ||||
| Tissue | −16.50 | 3.76 | 1.22 × 10−4 | |
| NFATC3-PLA2G15 | ||||
| Tissue | −15.23 | 4.40 | 0.001 | |
| Sex | −11.23 | 5.28 | 0.040 | |
| SHANK3-ACR | ||||
| Tissue | −25.61 | 3.95 | 4.27 × 10−8 | |
| SIRPB1-SIRPD | ||||
| Tissue | −18.94 | 3.76 | 2.29 × 10−5 |
1
Quantitative levels were rank-transformed to improve the normality distribution of values.
2
Tumor tissue as compared to non-involved tissue; males as compared to females; ever smoker as compared to never smoker; stage > I as compared to stage = I.
3
SE, standard error.
4
P values are reported only if P < 0.05; CTSC-RAB38 showed P > 0.05 for all variables.