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. 2016 Apr 4;7(19):27975–27987. doi: 10.18632/oncotarget.8564

Figure 4. Overexpression of KLF6 inhibits the migration and invasion of HCC cell lines.

Figure 4

A. Western blot analysis of basigin-2 expression in SMMC-7721 and Huh-7 cells treated with KLF6 plasmid or siRNA. B. Cell proliferation of these cells transfected as in (A) was measured in the indicated time periods using MTT proliferation assays. *, P < 0.05, two-way repeated measures ANOVA followed by the Bonferroni test. C. Wound-healing assays of SMMC-7721 and Huh-7 cells transfected as in (A), compared with control, at 24 h after transfection. Scale bars, 500 μm. *, P < 0.05, by one-way ANOVA followed by the Dunnett test. D. The inhibitory effect of KLF6 toward the invasion and migration of SMMC-7721 and Huh-7 cells. Scale bars, 200 μm. *, P < 0.05, by one-way ANOVA followed by the Dunnett test. KLF6/basigin-2 means to co-transfect basigin-2/pcDNA3.1 with KLF6/pcDNA3.1, whereas Si-KLF6/si-basigin-2 means to co-transfect si-KLF6 with si-basigin-2.