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. 2016 Mar 30;7(19):28027–28039. doi: 10.18632/oncotarget.8473

Figure 1. DNase hypersensitive sites identified within DMRs.

Figure 1

A. DC1B (chr1:240118001-240119000), identified as a DMR between CIMP and non-CIMP cells and located in an intergenic region downstream of the CHRM3 gene, is shown to possess DNase hypersensitive sites in 9 separate cell types by the ENCODE Consortium. B. DC15A (chr15: 65628001-65629000) overlaps intron 3, exon 4 and intron 4 of the IGDCC3 gene and has also be shown by ENCODE to be a highly DNase sensitive site by 38 cell types. Although both these regions are not located within a promoter region but these evidence indicate that DC1B and DC15A are regulatory DNA regions.