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. 2016 Mar 30;7(19):28027–28039. doi: 10.18632/oncotarget.8473

Table 1. Summary of information of related enhancer-DMR pairs.

Enhancer (VISTA) Chromo-some Enhancer's Chromosomal Coordinates DMR DMR's Chromosomal Coordinates Overlapping or Closest Gene (with/to DMR) Gene Accession Gene's Chromosomal Coordinates Strand (Gene) Distance of Enhancer from Gene TSS (bp)
1702 1 18958671- 18960284 DC1A 228194001- 228195000 Homo sapiens wingless-type MMTV integration site family, member 3A (WNT3A) NM_033131 228194722- 228248972 +ve 209,236,051
1702 1 18958671- 18960284 DC1B 240118001- 240119000 Homo sapiens cholinergic receptor, muscarinic 3 (CHRM3) NM_000740 239549876- 240078750 +ve 568,125
1944 15 65377669- 65381418 DC15A 65628001- 65629000 Homo sapiens immunoglobulin superfamily, DCC subclass, member 3 (IGDCC3) NM_004884 65619464- 65670378 −ve 288,960

Enhancer-DMR pairs that have a high degree of correlation in their DNA methylation patterns are shown in this table. For the purpose of this study, we have annotated the differentially methylated regions (DMRs) as DC1A, DC1B and DC15A. Two DMRs, DC1A and DC15A, were found to overlap genes, Wnt3A and IGDCC3, respectively, while the third DMR, DC1B, was found to be in close proximity to the gene, CHRM3. DC1B is located downstream of CHRM3 and so, although it is 568,125 bp from CHRM3′s transcription start site (TSS), it is, in reality, only 39,251 bp from the 3′-end of this gene.