Table 1. Summary of information of related enhancer-DMR pairs.
Enhancer (VISTA) | Chromo-some | Enhancer's Chromosomal Coordinates | DMR | DMR's Chromosomal Coordinates | Overlapping or Closest Gene (with/to DMR) | Gene Accession | Gene's Chromosomal Coordinates | Strand (Gene) | Distance of Enhancer from Gene TSS (bp) |
---|---|---|---|---|---|---|---|---|---|
1702 | 1 | 18958671- 18960284 | DC1A | 228194001- 228195000 | Homo sapiens wingless-type MMTV integration site family, member 3A (WNT3A) | NM_033131 | 228194722- 228248972 | +ve | 209,236,051 |
1702 | 1 | 18958671- 18960284 | DC1B | 240118001- 240119000 | Homo sapiens cholinergic receptor, muscarinic 3 (CHRM3) | NM_000740 | 239549876- 240078750 | +ve | 568,125 |
1944 | 15 | 65377669- 65381418 | DC15A | 65628001- 65629000 | Homo sapiens immunoglobulin superfamily, DCC subclass, member 3 (IGDCC3) | NM_004884 | 65619464- 65670378 | −ve | 288,960 |
Enhancer-DMR pairs that have a high degree of correlation in their DNA methylation patterns are shown in this table. For the purpose of this study, we have annotated the differentially methylated regions (DMRs) as DC1A, DC1B and DC15A. Two DMRs, DC1A and DC15A, were found to overlap genes, Wnt3A and IGDCC3, respectively, while the third DMR, DC1B, was found to be in close proximity to the gene, CHRM3. DC1B is located downstream of CHRM3 and so, although it is 568,125 bp from CHRM3′s transcription start site (TSS), it is, in reality, only 39,251 bp from the 3′-end of this gene.