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. 2016 Apr 4;7(19):28040–28058. doi: 10.18632/oncotarget.8575

Figure 1. Cell type in neuronal development of the DG and schematic experimental procedure.

Figure 1

A. Immunohistological markers for staging hippocampal neurogenesis. B. Age-dependent expression of PCNA, C. Sox2 and D. Dcx in the DG. Red arrows mark irradiation time (10D at 10W) and red solid symbols indicate the correspondent expression level for each marker; the value of the empty red symbol for Dcx has been extrapolated. DG image 4x magnification, scale bar = 200 μm; images of other markers: 100x magnifications, scale bar = 10 μm. E. 10D or 10W old mice were cranially irradiated with 0.1 or 2 Gy of X-rays and analysed at different time points. Bars indicate the times of tissue collection from sham or irradiated mouse groups. (1 and 7 days, 1 and 6 months postirradiation). The number of animals used for molecular analysis is n = 4-5, for behavioral tests is n = 20.