Table 3. Logistic regression analysis of associations of selected SNPs in IL-6, JAK1, JAK2 and STAT3 with gastric cancer risk in an eastern Chinese population.
| Variants | Genotype | Cases (N = 1,125) | Controls (N = 1,221) | Pa | Crude OR (95% CI) | P | Adjusted OR (95% CI) | Pb |
|---|---|---|---|---|---|---|---|---|
| IL-6 rs2069837 HWE_0.371 | AA | 739 (65.7) | 873 (71.5) | 0.002c | 1.00 | 1.00 | ||
| AG | 354 (31.5) | 314 (25.7) | 1.33(1.11-1.60) | 0.002 | 1.35 (1.01-1.45) | 0.001 | ||
| GG | 32 (2.8) | 34 (2.8) | 1.11 (0.68-1.82) | 0.673 | 1.14 (0.69-1.87) | 0.611 | ||
| AG+GG | 386 (34.3) | 348 (28.5) | 0.002d | 1.31 (1.10-1.56) | 0.003 | 1.33 (1.12-1.59) | 0.002 | |
| AA+AG | 1093 (97.2) | 1187 (97.2) | 1.00 | 1.00 | ||||
| GG | 32 (2.8) | 47 (3.85) | 0.930e | 1.02(0.63-1.67) | 0.930 | 1.04 (0.64-1.71) | 0.873 | |
| IL-6 rs2069840 HWE_0.140 | CC | 987 (87.7) | 1043 (85.4) | 0.203c | 1.00 | 1.00 | ||
| CG | 132 (11.7) | 167 (13.7) | 0.84 (0.65-1.07) | 0.149 | 0.80 (0.63-1.03) | 0.079 | ||
| GG | 6 (0.5) | 11 (0.90) | 0.58(0.21-1.57) | 0.280 | 0.57 (0.21-1.55) | 0.270 | ||
| CG+GG | 138 (12.3) | 178 (14.6) | 0.101d | 0.82 (0.65-1.04) | 0.102 | 0.79 (0.62-1.01) | 0.052 | |
| CC+CG | 1119 (99.5) | 1210 (99.1) | 1.00 | 1.00 | ||||
| GG | 6 (0.5) | 11 (0.90) | 0.294e | 0.59 (0.22-1.60) | 0.230 | 0.58 (0.21-1.60) | 0.295 | |
| JAK1 rs10889513 HWE_0.103 | GG | 381 (33.9) | 441 (36.1) | 0.264c | 1.00 | 1.00 | ||
| GA | 598 (53.1) | 608 (49.8) | 1.14 (1.03-1.47) | 0.153 | 1.15 (0.96-1.37) | 0.140 | ||
| AA | 146 (13.0) | 172 (14.1) | 0.98 (0.76-1.27) | 0.895 | 0.97 (0.75-1.27) | 0.844 | ||
| GA+AA | 744 (66.1) | 780 (63.9) | 0.254d | 1.10 (0.93-1.31) | 0.254 | 1.11 (0.93-1.32) | 0.247 | |
| GG+GA | 979 (87.0) | 1049 (85.9) | 1.00 | 1.00 | ||||
| AA | 146 (13.0) | 184 (14.1) | 0.433e | 0.91 (0.72-1.15) | 0.434 | 0.90 (0.71-1.14) | 0.383 | |
| JAK1 rs2230587 HWE_0.657 | GG | 554 (49.2) | 653 (53.5) | 0.067c | 1.00 | 1.00 | ||
| GA | 473 (42.0) | 484 (39.6) | 1.15 (0.97-1.37) | 0.103 | 1.16 (0.98-1.37) | 0.092 | ||
| AA | 98 (8.7) | 84 (6.9) | 1.38 (1.01-1.88) | 0.046 | 1.43 (1.04-1.96) | 0.026 | ||
| GA+AA | 571 (50.8) | 568 (46.5) | 0.040d | 1.19 (1.01-1.39) | 0.040 | 1.20 (1.02-1.43) | 0.030 | |
| GG+GA | 1027 (91.3) | 1137 (93.1) | 1.00 | 1.00 | ||||
| AA | 98 (8.7) | 84 (6.9) | 0.098e | 1.29 (0.95-1.75) | 0.098 | 0.34 (0.99-1.82) | 0.061 | |
| JAK2 rs1887429 HWE_0.391 | GG | 773 (68.7) | 867 (71.0) | 0.419c | 1.00 | 1.00 | ||
| GT | 313 (27.8) | 319 (26.1) | 1.10 (0.92-1.32) | 0.307 | 1.12 (0.93-1.34) | 0.250 | ||
| TT | 39 (3.5) | 35 (2.9) | 1.25 (0.78-1.99) | 0.349 | 1.26 (0.79-2.02) | 0.333 | ||
| GT+TT | 352 (31.3) | 354 (29.0) | 0.226d | 1.12 (0.94-1.33) | 0.226 | 1.13 (0.95-1.35) | 0.180 | |
| GG+TG | 1086 (96.5) | 1186 (97.1) | 1.00 | 1.00 | ||||
| TT | 39 (3.5) | 35 (2.9) | 0.406e | 1.22 (0.77-1.94) | 0.406 | 1.23 (0.77-1.96) | 0.396 | |
| JAK2 rs3808850 HWE_0.189 | TT | 347 (30.8) | 373 (30.6) | 0.977c | 1.00 | 1.00 | ||
| TA | 575 (50.1) | 624 (51.0) | 0.99 (0.82-1.19) | 0.920 | 0.99 (0.82-1.19) | 0.899 | ||
| AA | 203 (18.0) | 224 (18.4) | 0.97 (0.77-1.24) | 0.831 | 1.00 (0.78-1.27) | 0.983 | ||
| TA+AA | 778 (69.2) | 848 (69.5) | 0.877d | 0.99 (0.83-1.18) | 0.877 | 0.99 (0.83-1.18) | 0.915 | |
| TT+TA | 922 (82.0) | 997 (81.7) | 1.00 | 1.00 | ||||
| AA | 203 (18.0) | 224 (18.3) | 0.850e | 0.98 (0.79-1.21) | 0.850 | 1.01 (0.81-1.24) | 0.963 | |
| JAK2 rs6476933 HWE_0.683 | CC | 531 (47.2) | 570 (46.7) | 0.892c | 1.00 | 1.00 | ||
| CT | 481 (42.8) | 533 (43.7) | 0.97 (0.82-1.15) | 0.915 | 0.97 (0.82-1.16) | 0.767 | ||
| TT | 113 (10.0) | 118 (9.6) | 1.03 (0.77-1.37) | 0.849 | 1.04 (0.78-1.39) | 0.775 | ||
| CT+TT | 594 (52.8) | 651 (53.3) | 0.802d | 0.98 (0.83-1.15) | 0.802 | 0.99 (0.84-1.16) | 0.872 | |
| CC+CT | 1012 (90.0) | 1103 (90.3) | 1.00 | 1.00 | ||||
| TT | 113 (10.0) | 118 (9.7) | 0.758e | 1.04 (0.80-1.37) | 0.757 | 1.06 (0.80-1.39) | 0.698 | |
| STAT3 rs1053004 HWE_0.067 | AA | 445 (39.6) | 432 (35.4) | 0.044c | 1.00 | 1.00 | ||
| AG | 549 (48.8) | 614 (50.3) | 0.87 (0.73-1.03) | 0.114 | 0.87 (0.73-1.04) | 0.117 | ||
| GG | 131 (11.6) | 175 (15.3) | 0.73 (0.56-0.95) | 0.017 | 0.75 (0.58-0.98) | 0.035 | ||
| AG+GG | 680 (60.4) | 789 (64.6) | 0.037d | 0.84 (0.71-0.99) | 0.037 | 0.84 (0.71-0.99) | 0.048 | |
| AA+AG | 994 (88.4) | 1046 (85.9) | 1.00 | 1.00 | ||||
| GG | 131 (11.6) | 175 (14.1) | 0.053e | 0.79 (0.62-1.01) | 0.053 | 0.82 (0.64-1.04) | 0.103 | |
| STAT3 rs1053005 HWE_0.138 | TT | 525 (46.7) | 610 (50.0) | 0.209c | 1.00 | 1.00 | ||
| TC | 502 (44.6) | 521 (42.6) | 1.12 (0.95-1.33) | 0.191 | 1.14 (0.96-1.35) | 0.148 | ||
| CC | 98 (8.7) | 90 (7.4) | 1.27 (0.93-1.72) | 0.136 | 1.29 (0.95-1.77) | 0.108 | ||
| TC+CC | 600 (53.3) | 611(50.0) | 0.111d | 1.14 (0.97-1.34) | 0.111 | 1.16 (0.98-1.37) | 0.080 | |
| TT+TC | 1027 (91.3) | 1131 (92.6) | 1.00 | 1.00 | ||||
| CC | 98 (8.7) | 90 (7.4) | 0.232e | 1.20 (0.89-1.62) | 0.232 | 1.22 (0.90-1.65) | 0.203 | |
| STAT3 rs4796793 HWE_0.823 | CC | 431 (38.3) | 478 (39.2) | 0.560c | 1.00 | 1.00 | ||
| CG | 548 (48.7) | 569 (46.6) | 1.07 (0.90-1.27) | 0.461 | 1.08 (0.90-1.29) | 0.405 | ||
| GG | 146 (13.0) | 174 (16.3) | 0.93 (0.72-1.20) | 0.582 | 0.97 (0.75-1.26) | 0.813 | ||
| CG+GG | 694 (61.7) | 743 (60.9) | 0.678d | 1.04 (0.88-1.22) | 0.678 | 1.05 (0.89-1.25) | 0.546 | |
| CC+CG | 979 (87.0) | 1047 (85.8) | 1.00 | 1.00 | ||||
| GG | 146 (13.0) | 174 (14.2) | 0.370e | 0.90 (0.71-1.14) | 0.371 | 0.93 (0.73-1.18) | 0.550 |
Abbreviation: SNP, single nucleotide polymorphism; CI, confidence interval; OR, odds ratio.
a
Chi square test for genotype distributions between cases and controls.
b
Adjustment without (crude) and with age, sex, smoking and drinking status in logistic regression models.
c
For additive genetic models.
d
For dominant genetic models.
e
For recessive genetic models.