Table 4. Combined effects of risk genotypes of IL-6 and JAK1 SNPs on GCa risk in an eastern Chinese population.
| NRG* | Cases (%) | Controls (%) | Pa | Crude OR (95% CI) | Pb | Adjusted OR (95% CI) | Pb |
|---|---|---|---|---|---|---|---|
| 0 | 365 (32.4) | 474 (38.9) | 0.002 | 1.00 | 1.00 | ||
| 1 | 563 (50.0) | 578 (47.3) | 1.26 (1.06-1.51) | 0.010 | 1.27 (1.06-1.53) | 0.009 | |
| 2 | 197 (17.5) | 169 (13.8) | 1.51 (1.18-1.94) | 0.001 | 1.56 (1.22-2.01) | 0.001 | |
| Trend test | 0.004 | 0.0002 | |||||
| 0 | 365 (32.4) | 474 (38.8) | 0.001 | 1.00 | 1.00 | ||
| 1-2 | 760 (67.6) | 747 (61.2) | 1.32 (1.12-1.57) | 0.001 | 1.34 (1.13-1.59) | 0.001 | |
a
Chi-square test was used to calculate the genotype frequency distributions.
b
Obtained in logistic regression models without (crude) and with adjustment for age, sex, smoking and drinking status.
*
NRG: numbers of risk genotypes; The risk genotypes include rs2069837 AG/GG and rs2230587 GA/AA.