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. 2016 Apr 5;7(19):28235–28246. doi: 10.18632/oncotarget.8595

Figure 1. Effects of metformin on bladder cancer development.

Figure 1

A. The experimental scheme of cancer induction and metformin treatment. B–D. The effects of metformin on bladder cancer initiation and progression. Bladder tissues from the animals treated with or without metformin were collected and stained with H&E at week 3 (B), week 6 (C) and week 12 (D). E. The numbers of different lesions in each animal at different time points were counted and the averages of lesions in the animals treated with and without metformin were plotted. (B–D) Magnifications: X400.