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. 2016 Apr 5;7(19):28301–28319. doi: 10.18632/oncotarget.8597

Figure 6. β2-chimaerin deficiency correlates with lower mammary tumor grade.

Figure 6

A. Tumor growth rate in Neu/β2WT and Neu/β2KO mice. Tumor growth was analyzed for 6 weeks after tumor onset by weekly measurement of tumor volume. Data were represented on a semilogaritmic scale and fitted by linear regression. Slopes for each growth curve are represented (P = 0.089, Mann Whitney U-test). B. Tumor burden in Neu/β2WT and Neu/β2KO mice (P = 0.74, Mann Whitney U-test). C. Representative images of H&E staining of Neu/β2WT and Neu/β2KO tumors (10×) showing poorly differentiated carcinomas (a, d), a moderately differentiated carcinoma (e), a tumor with hemorrhagic areas (b), and tumors with necrotic areas (c, f). D. Grade distribution of tumors according to the modified Elston and Ellis grading system (*P < 0.05, two tailed Fisher's exact test).