Skip to main content
. 2016 Apr 5;7(19):28301–28319. doi: 10.18632/oncotarget.8597

Figure 8. Deletion of β2-chimaerin in MMTV-Neu mice favors the maintenance of the epithelial state of breast tumors.

Figure 8

A. Representative images of E-cadherin staining in tumors of the indicated genotypes collected after three months from tumor onset. B-C. Western blot analysis of the expression of E-cadherin, β-catenin and vimentin in tumor lysates from Neu/β2WT and Neu/β2KO mice collected after 3 months from tumor onset (B) (same tumors as in Figure 6B), or after 1 month from tumor onset (C). Densitometric analysis of the expression of each protein normalized to actin expression is shown in the histograms. In B: P = 0.69 for E-cadherin, P = 0.87 for β-catenin and P = 0.17 for vimentin expression; in C: P = 0.81 for E-cadherin, P = 1.00 for β-catenin and P = 0.07 for vimentin (Mann Whitney U-test). Results are presented as means ± s.e.m.