Table 1. Highly expressed genes putatively regulated by miR-145-5p and miR-145-3p.
| Entrez Gene ID | Gene Symbol | Description | Genomic location | Gene Expression Omnibus (GSE11783 + GSE31684) | Expression in miR-145-5ptransfectant (Log2 FC) | Expression in miR-145-3ptransfectant (Log2 FC) | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Expression | Log2 FC | P-value | T24 | BOY | T24 | BOY | ||||
| 29128 | UHRF1 | ubiquitin-like with PHD and ring finger domains 1 | 19p13.3 | up | 4.984 | 1.049E-03 | −0.041 | −0.274 | −0.334 | −0.901 |
| 54972 | TMEM132A | transmembrane protein 132A | 11q12.2 | up | 3.458 | 1.049E-03 | −0.006 | −0.087 | −0.178 | −0.140 |
| 4288 | MKI67 | marker of proliferation Ki-67 | 10q26.2 | up | 3.182 | 1.049E-03 | −0.070 | −0.022 | −0.609 | −0.872 |
| 1111 | CHEK1 | checkpoint kinase 1 | 11q24.2 | up | 2.841 | 1.049E-03 | −0.354 | −0.204 | −0.426 | −0.583 |
| 25886 | POC1A | POC1 centriolar protein A | 3p21.2 | up | 2.354 | 1.049E-03 | −0.146 | −0.194 | −0.251 | −0.161 |
| 400745 | SH2D5 | SH2 domain containing 5 | 1p36.12 | up | 2.299 | 1.049E-03 | −0.512 | −0.075 | −0.136 | −0.038 |
| 55215 | FANCI | Fanconi anemia, complementation group I | 15q26.1 | up | 2.188 | 1.049E-03 | −0.031 | −0.079 | −0.281 | −0.320 |
| 51512 | GTSE1 | G-2 and S-phase expressed 1 | 22q13.31 | up | 2.147 | 1.049E-03 | −0.028 | −0.149 | −0.713 | −0.209 |
| 157570 | ESCO2 | establishment of sister chromatid cohesion N-acetyltransferase 2 | 8p21.1 | up | 2.028 | 1.049E-03 | −0.441 | −0.352 | −0.585 | −0.166 |
| 2175 | FANCA | Fanconi anemia, complementation group A | 16q24.3 | up | 1.877 | 1.049E-03 | −0.017 | −0.166 | −0.412 | −0.532 |
| 6624 | FSCN1 | fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) | 7p22.1 | up | 1.829 | 2.942E-03 | −2.899 | −0.732 | −0.175 | −1.133 |
| 22979 | EFR3B | EFR3 homolog B (S. cerevisiae) | 2p23.3 | up | 1.803 | 1.247E-03 | −0.312 | −0.033 | −1.189 | −1.625 |
| 3918 | LAMC2 | laminin, gamma 2 | 1q25.3 | up | 1.797 | 1.791E-02 | −0.839 | −0.707 | −0.125 | −0.608 |
| 8349 | HIST2H2BE | histone cluster 2, H2be | 1q21.2 | up | 1.764 | 1.524E-03 | −0.266 | −0.149 | −0.524 | −0.170 |
| 9455 | HOMER2 | homer homolog 2 (Drosophila) | 15q25.2 | up | 1.706 | 2.526E-03 | −0.360 | −0.278 | −0.132 | −0.305 |
| 25902 | MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 6q25.1 | up | 1.611 | 1.049E-03 | −0.307 | −0.024 | −0.617 | −0.505 |
| 55732 | C1orf112 | chromosome 1 open reading frame 112 | 1q24.2 | up | 1.461 | 1.685E-03 | −0.099 | −0.147 | −0.030 | −0.132 |
| 388389 | CCDC103 | coiled-coil domain containing 103 | 17q21.31 | up | 1.390 | 3.290E-02 | −0.327 | −0.266 | −2.471 | −1.838 |
| 6566 | SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 1p13.2 | up | 1.359 | 3.893E-02 | −0.229 | −0.137 | −0.759 | −1.259 |
| 23178 | PASK | PAS domain containing serine/threonine kinase | 2q37.3 | up | 1.333 | 1.058E-03 | −0.016 | −0.001 | −0.218 | −0.443 |
| 5426 | POLE | polymerase (DNA directed), epsilon, catalytic subunit | 12q24.33 | up | 1.241 | 1.247E-03 | −0.094 | −0.424 | −0.295 | −0.051 |
| 55379 | LRRC59 | leucine rich repeat containing 59 | 17q21.33 | up | 1.233 | 1.049E-03 | −0.155 | −0.198 | −0.289 | −0.283 |
| 6715 | SRD5A1 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 5p15.31 | up | 1.170 | 5.069E-03 | −0.329 | −0.018 | −0.823 | −0.837 |
| 4602 | MYB | v-myb avian myeloblastosis viral oncogene homolog | 6q23.3 | up | 1.160 | 4.501E-03 | −0.105 | −0.337 | −0.111 | −1.418 |
| 8940 | TOP3B | topoisomerase (DNA) III beta | 22q11.22 | up | 1.157 | 9.078E-03 | −0.108 | −0.021 | −0.840 | −1.150 |
| 64768 | IPPK | inositol 1,3,4,5,6-pentakisphosphate 2-kinase | 9q22.31 | up | 1.153 | 1.072E-03 | −0.526 | −0.102 | −0.630 | −0.296 |
| 9266 | CYTH2 | cytohesin 2 | 19q13.33 | up | 1.127 | 1.049E-03 | −0.226 | −0.104 | −0.598 | −0.377 |
| 221468 | TMEM217 | transmembrane protein 217 | 6p21.2 | up | 1.081 | 4.734E-02 | −0.049 | −0.008 | −0.033 | −0.337 |
| 25859 | PART1 | prostate androgen-regulated transcript 1 (non-protein coding) | 5q12.1 | up | 1.025 | 4.873E-03 | −0.144 | −0.212 | −0.097 | −0.694 |
| 8566 | PDXK | pyridoxal (pyridoxine, vitamin B6) kinase | 21q22.3 | up | 1.014 | 1.316E-03 | −0.039 | −0.842 | −0.567 | −0.558 |
| 11072 | DUSP14 | dual specificity phosphatase 14 | 17q12 | up | 1.008 | 2.440E-03 | −0.126 | −0.092 | −0.924 | −1.020 |
| 23516 | SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 8p21.3 | up | 0.999 | 3.435E-03 | −0.540 | −0.216 | −2.083 | −1.548 |
| 85414 | SLC45A3 | solute carrier family 45, member 3 | 1q32.1 | up | 0.977 | 3.435E-03 | −0.578 | −0.086 | −0.782 | −0.505 |
| 1163 | CKS1B | CDC28 protein kinase regulatory subunit 1B | 1q21.3 | up | 0.941 | 1.857E-02 | −0.370 | −0.229 | −0.678 | −0.802 |
| 79929 | MAP6D1 | MAP6 domain containing 1 | 3q27.1 | up | 0.927 | 1.093E-03 | −0.135 | −0.210 | −0.928 | −0.529 |
| 65985 | AACS | acetoacetyl-CoA synthetase | 12q24.31 | up | 0.919 | 1.058E-03 | −0.555 | −0.367 | −0.816 | −0.798 |
| 1263 | PLK3 | polo-like kinase 3 | 1p34.1 | up | 0.910 | 1.685E-03 | −0.229 | −0.092 | −1.766 | −2.103 |
| 64785 | GINS3 | GINS complex subunit 3 (Psf3 homolog) | 16q21 | up | 0.891 | 1.740E-03 | −0.185 | −0.218 | −0.853 | −0.826 |
| 4957 | ODF2 | outer dense fiber of sperm tails 2 | 9q34.11 | up | 0.854 | 1.185E-03 | −0.232 | −0.409 | −0.610 | −0.963 |
| 57613 | KIAA1467 | KIAA1467 | 12p13.1 | up | 0.837 | 4.169E-03 | −0.382 | −0.282 | −0.398 | −0.456 |
| 7525 | YES1 | v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 | 18p11.32 | up | 0.794 | 2.526E-03 | −0.382 | −0.447 | −0.256 | −0.446 |
| 8751 | ADAM15 | ADAM metallopeptidase domain 15 | 1q22 | up | 0.787 | 6.433E-03 | −0.233 | −0.217 | −0.383 | −0.318 |
| 7172 | TPMT | thiopurine S-methyltransferase | 6p22.3 | up | 0.786 | 1.524E-03 | −0.167 | −0.032 | −0.482 | −0.323 |
| 4615 | MYD88 | myeloid differentiation primary response 88 | 3p22.2 | up | 0.759 | 1.947E-03 | −0.662 | −0.118 | −0.286 | −0.113 |
| 1678 | TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | Xq22.1 | up | 0.729 | 2.723E-03 | −0.530 | −0.187 | −0.201 | −0.267 |
| 3927 | LASP1 | LIM and SH3 protein 1 | 17q12 | up | 0.692 | 2.348E-03 | −0.280 | −0.014 | −0.319 | −0.069 |
| 10295 | BCKDK | branched chain ketoacid dehydrogenase kinase | 16p11.2 | up | 0.685 | 6.186E-03 | −0.281 | −0.161 | −0.439 | −0.246 |
| 26088 | GGA1 | golgi-associated, gamma adaptin ear containing, ARF binding protein 1 | 22q13.1 | up | 0.668 | 1.049E-03 | −0.010 | −0.074 | −0.180 | −0.202 |
| 6240 | RRM1 | ribonucleotide reductase M1 | 11p15.4 | up | 0.667 | 4.582E-02 | −0.206 | −0.207 | −1.158 | −2.292 |
| 219902 | TMEM136 | transmembrane protein 136 | 11q23.3 | up | 0.667 | 3.574E-03 | −0.449 | −0.477 | −0.386 | −0.405 |
| 7019 | TFAM | transcription factor A, mitochondrial | 10q21.1 | up | 0.644 | 1.274E-02 | −0.163 | −0.413 | −0.543 | −0.609 |
| 55775 | TDP1 | tyrosyl-DNA phosphodiesterase 1 | 14q32.11 | up | 0.624 | 1.316E-03 | −0.151 | −0.193 | −0.651 | −0.188 |
| 79858 | NEK11 | NIMA-related kinase 11 | 3q22.1 | up | 0.613 | 1.626E-03 | −0.628 | −0.563 | −0.179 | −0.189 |
| 1889 | ECE1 | endothelin converting enzyme 1 | 1p36.12 | up | 0.604 | 3.635E-02 | −0.949 | −0.274 | −0.559 | −0.639 |
| 65264 | UBE2Z | ubiquitin-conjugating enzyme E2Z | 17q21.32 | up | 0.590 | 1.348E-03 | −0.352 | −0.187 | −0.895 | −1.241 |
| 9205 | ZMYM5 | zinc finger, MYM-type 5 | 13q12.11 | up | 0.582 | 7.805E-03 | −0.413 | −0.381 | −0.699 | −0.890 |
| 996 | CDC27 | cell division cycle 27 | 17q21.32 | up | 0.572 | 9.799E-03 | −0.486 | −0.018 | −0.260 | −0.099 |
| 22898 | DENND3 | DENN/MADD domain containing 3 | 8q24.3 | up | 0.570 | 1.016E-02 | −0.235 | −0.012 | −0.597 | −0.926 |
| 84314 | TMEM107 | transmembrane protein 107 | 17p13.1 | up | 0.570 | 2.965E-02 | −0.471 | −0.208 | −0.199 | −0.839 |
| 85464 | SSH2 | slingshot protein phosphatase 2 | 17q11.2 | up | 0.562 | 2.440E-03 | −0.296 | −0.173 | −0.433 | −0.220 |
| 56180 | MOSPD1 | motile sperm domain containing 1 | Xq26.3 | up | 0.559 | 1.928E-02 | −0.145 | −0.237 | −1.352 | −1.270 |
| 6625 | SNRNP70 | small nuclear ribonucleoprotein 70kDa (U1) | 19q13.33 | up | 0.554 | 1.725E-02 | −0.373 | −0.281 | −0.663 | −0.988 |
| 60490 | PPCDC | phosphopantothenoyl- cysteine decarboxylase |
15q24.2 | up | 0.550 | 1.182E-02 | −0.269 | −0.338 | −0.057 | −0.130 |
| 147657 | ZNF480 | zinc finger protein 480 | 19q13.41 | up | 0.547 | 3.893E-02 | −0.453 | −0.035 | −0.107 | −0.047 |
| 159090 | FAM122B | family with sequence similarity 122B | Xq26.3 | up | 0.543 | 2.865E-02 | −0.356 | −0.131 | −1.379 | −1.493 |
| 3150 | HMGN1 | high mobility group nucleosome binding domain 1 |
21q22.2 | up | 0.522 | 7.521E-03 | −0.884 | −0.157 | −0.162 | −0.119 |
| 7421 | VDR | vitamin D (1,25-dihydroxyvitamin D3) receptor | 12q13.11 | up | 0.494 | 3.290E-02 | −0.001 | −0.069 | −0.428 | −0.417 |
| 84705 | GTPBP3 | GTP binding protein 3 (mitochondrial) | 19p13.11 | up | 0.485 | 1.999E-02 | −0.156 | −0.048 | −0.488 | −1.061 |
| 84818 | IL17RC | interleukin 17 receptor C | 3p25.3 | up | 0.478 | 8.102E-03 | −0.306 | −0.009 | −0.053 | −0.194 |
| 10102 | TSFM | Ts translation elongation factor, mitochondrial | 12q14.1 | up | 0.475 | 4.873E-03 | −0.170 | −0.026 | −0.951 | −0.608 |
| 27 | ABL2 | c-abl oncogene 2, non-receptor tyrosine kinase | 1q25.2 | up | 0.455 | 9.799E-03 | −0.211 | −0.281 | −0.230 | −0.102 |
| 55285 | RBM41 | RNA binding motif protein 41 |
Xq22.3 | up | 0.415 | 1.538E-02 | −0.055 | −0.215 | −0.495 | −0.559 |
| 57532 | NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 17q11.2 | up | 0.397 | 1.056E-02 | −0.098 | −0.256 | −0.425 | −0.904 |
| 84445 | LZTS2 | leucine zipper, putative tumor suppressor 2 | 10q24.31 | up | 0.394 | 4.155E-02 | −0.174 | −0.125 | −0.288 | −0.026 |
| 8243 | SMC1A | structural maintenance of chromosomes 1A | Xp11.22 | up | 0.390 | 3.635E-02 | −0.163 | −0.061 | −0.917 | −0.297 |
| 54617 | INO80 | INO80 complex subunit | 15q15.1 | up | 0.384 | 2.835E-03 | −0.594 | −0.006 | −0.635 | −0.350 |
| 7511 | XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 10q25.1 | up | 0.381 | 7.521E-03 | −0.648 | −0.272 | −1.595 | −1.701 |
| 23367 | LARP1 | La ribonucleoprotein domain family, member 1 | 5q33.2 | up | 0.377 | 4.155E-02 | −0.049 | −0.003 | −0.091 | −0.216 |
| 10146 | G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 5q33.1 | up | 0.313 | 4.021E-02 | −1.431 | −0.040 | −0.505 | −0.475 |