Table 1. Comparison of the accuracy of predictions using different in vivo data.
| Drug | Group | Within a 2-fold error | Outside a 2-fold error | χ2 P-value | ||
|---|---|---|---|---|---|---|
| Number | Percentage | Number | Percentage | |||
| Omeprazole | Control | 55 | 53.92 | 47 | 46.08 | 0.480 |
| HCC | 60 | 58.82 | 42 | 41.18 | ||
| Midazolam | Control | 95 | 93.14 | 7 | 6.86 | 1.000 |
| HCC | 95 | 93.14 | 7 | 6.86 | ||
Control: using a correction coefficient that applies to patients with normal liver function. HCC: using a correction coefficient calculated based on in vivo clearance in patients with cirrhosis.