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Stimulation of Gq/G11-coupled P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6 and P2Y11) activates PLC/IP3 pathway to induce intracellular calcium release from the endoplasmic reticulum (ER). An increase in intracellular calcium concentrations would increase the proliferation or apoptosis of different digestive cancer cells.
