Table 2.

Mean±SD change in 24-hour urine ion excretion in the dosing regimen study averaged across dosing regimens by collection analysis (preplanned and sensitivity)

Analysis Period	Patiromer at 25.2 g/d Averaged across Dosing Regimens	P Valuea
4-d Preplanned analysis (days 1–4 versus 19–22)
uK, mg	−1462.1±274.3	<0.001
uNa, mg	−463.2±581.7	0.02
uMg, mg	−39.1±20.0	<0.001
uCa, mg	73.5±38.8	<0.001
uP, mg	−143.5±138.1	<0.01
2-d Sensitivity analysis (days 3 and 4 versus 21 and 22)
uK, mg	−1800.2±312.7	<0.001
uNa, mg	−80.5±636.0	0.32
uMg, mg	−49.5±17.8	<0.001
uCa, mg	83.3±40.4	<0.001
uP, mg	−109.3±134.5	<0.02

uK, urine potassium; uNa, urine sodium; uMg, urine magnesium; uCa, urine calcium; uP, urine phosphate.

^aFrom one–sample t test to determine if the mean change from baseline is significantly different from zero.