Table 3.

Mean±SD 24-hour urine calcium, phosphate, potassium, sodium, and magnesium excretion in the dosing regimen study (4-day preplanned analysis)

Urine Analyte	Patiromer Dosing Regimen
	8.4 g Three Times per d	12.6 g Two Times per d	25.2 g One Time per d
uCa, mg
Baseline	143±82	143±82	143±82
Treatment	216±97	209±97	196±90a
Change from baseline	73±39	66±34	53±26a
uP, mg
Baseline	890±158	890±158	890±158
Treatment	733±99	741±102	793±103b,c
Change from baseline	−157±124	−150±119	−97±134b,c
uK, mg
Baseline	4450±362	4450±362	4450±362
Treatment	3010±474	2916±327	3012±446
Change from baseline	−1440±384	−1534±295	−1438±384
uNa, mg
Baseline	2869±488	2869±488	2869±488
Treatment	2288±268	2442±306	2323±247
Change from baseline	−581±536	−428±603	−546±693
uMg, mg
Baseline	134±37	134±37	134±37
Treatment	95±23	91±23	100±23
Change from baseline	−39±22	−43±18	−34±21

uCa, urine calcium; uP, urine phosphate; uK, urine potassium; uNa, urine sodium; uMg, urine magnesium.

^aP=0.01 versus three times per day for pairwise comparison between regimens from t test.

^bP<0.01 versus three times per day for pairwise comparison between regimens from t test.

^cP=0.02 versus two times per day for pairwise comparison between regimens from t test.