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. Author manuscript; available in PMC: 2016 Oct 6.
Published in final edited form as: J Neurophysiol. 2007 Jul 5;98(3):1526–1537. doi: 10.1152/jn.00564.2007

FIG. 3.

FIG. 3

Muscarinic receptor activation leads to an increase in burst firing in vivo. A: interspike interval (ISI) histograms before (blue), during (red), and after (green) application of carbachol. Carbachol leads to an increase in ISIs <10 ms. B: ISI histograms before (blue), during (red), and after (green) application of carbachol in the presence of atropine. Atropine prevents the effect of carbachol revealing muscarinic receptor activation by carbachol. C: bar graph representing the average increase of the burst fraction (fraction of ISIs <10 ms; control: 0.11 ± 0.10; carbachol: 0.24 ± 0.15, P = 0.001, paired t-test, n = 14) after carbachol and return to control levels after recovery period. (D) Atropine prevents an increase in burst fraction for the population of cells tested.