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. Author manuscript; available in PMC: 2017 Aug 24.
Published in final edited form as: J Toxicol Environ Health A. 2016 Aug 24;79(21):984–997. doi: 10.1080/15287394.2016.1211045

Figure 7.

Figure 7

Relationship between various mechanisms and biological effects associated with potential male infertility in mice exposed to CNC via pharyngeal aspiration. The schema proposes the extrapulmonary translocation of CNC particles to distant organs and briefly illustrates how enhanced oxidative stress can cause changes at different levels of male reproductive organs, leading to male infertility. The precise mechanisms that are modulated or perturbed in the testis and in the epididymis of CNC-exposed mice are highlighted in Arial red font and Script MT green font, respectively.