. Author manuscript; available in PMC: 2016 Oct 6.

Published in final edited form as: J Am Chem Soc. 2016 Sep 26;138(39):12975–12980. doi: 10.1021/jacs.6b07395

Table 1.

Bacterial phosphotransferase activities and MICs against M. tuberculosis

Compound	WecA inhibition IC₅₀ (μM)^a	MurX inhibition IC₅₀ (μM)^a	M. tuberculosis growth inhibition [MIC₅₀ (μg/mL)]^b
Muraymycin D1 (1)	0.69	0.011	1.56
Muraymycin D1-amide (2)	0.66	0.011	1.56
Muraymycin D1-diamide (3)	0.070	0.0096	6.25
Tunicamycin	0.15	3.38	3.13
Capuramycin	–	0.22	6.25
UT-01320	0.060	–	1.56

WecA and MurX assays (see SI).

A microdilution broth method was used. All structures in Table 1 are shown in SI.