Table 1.
Characteristics of study population by direction of MA/Cr change.
| Urine MA/Cr decrease 53.35% (n = 199) | Urine MA/Cr increase 46.65% (n = 174) | Total n = 373 | p-value | |
|---|---|---|---|---|
| Time, years between first and last | 3.13 (1.19) | 3.12 (1.12) | 3.12 (1.16) | 0.93 |
| Urine MA/Cr change median (25th, 75th ‰), µg/mg | −4 (−10, −2) | 3 (1, 11) | −1 (−4, 2) | <0.001 |
| Age, years (SD) | 9.64 (5.16) | 10.86 (5.25) | 10.21 (5.23) | 0.03 |
| Sex (male), % (n) | 48.91 (90) | 51.09 (94) | 49.46 (184) | 0.10 |
| Serum albumin, g/dL (SD) | 4.09 (0.30) | 4.09 (0.29) | 4.09 (0.30) | 0.97 |
| Serum creatinine mg/dL (SD) | 0.43 (0.18) | 0.45 (0.17) | 0.44 (0.18) | 0.34 |
| Hemoglobin, g/dL (SD) | 9.34 (1.78) | 9.34 (1.63) | 9.34 (1.71) | 0.98 |
| Hemoglobin A2, % (SD) | 3.67 (0.85) | 3.68 (0.93) | 3.67 (0.88) | 0.97 |
| Hemoglobin F, % (SD) | 9.09 (7.99) | 7.43 (7.17) | 8.32 (7.65) | 0.04 |
| Hemoglobin S, % (SD) | 67.01 (19.60) | 63.37 (20.39) | 65.31 (20.02) | 0.08 |
| Total bilirubin, mg/dL (SD) | 2.55 (2.29) | 2.26 (2.00) | 2.42 (2.00) | 0.16 |
| First (baseline) MA/Cr, µg/mg | 30 (103) | 16 (57) | 23 (85) | 0.11 |
| Last MA/Cr, µg/mg | 11 (29) | 100 (642) | 53 (440) | 0.05 |
| Blood transfusion, yes % (n) | 49.75 (99) | 55.75 (97) | 52.55 (196) | 0.25 |
| ACEi/ARB, yes % (n) | 3.52 (7) | 6.32 (11) | 4.83 (18) | 0.21 |
| Hydroxyurea, yes % (n) | 13.07 (26) | 16.09 (28) | 14.48 (54) | 0.41 |
| Both ACEi/ARB and hydroxyurea | 2.51 (5) | 2.30 (4) | 2.41 (9) | 1.00 |