Table 4.
Cytotoxic activity (IC50 μg ml−1) of the marine actinomycetes crude extracts against HCT116 human colon carcinoma cells for 72 h.
| Strain/Extract code | GenBank accession number | Strain description | HCT116 bioassay ICa50 (μg ml−1) | Archipelago location | Habitat | GenBank accession number |
|---|---|---|---|---|---|---|
| PTM-15 | KT446086 | Streptomyces anulatus NRRL B2000 | 6.00 | Desertas | H11 | DQ026637.1 |
| PTM-19 | KT446177 | Streptomyces carpaticus NBRC 15390 | 8.68 | Madeira | H2 | NR_112450.1 |
| PTM-34 | KT446147 | Streptomyces hydrogenans NBRC 13475 | 9.70 | Madeira | H8 | AB184868.1 |
| PTM-36 | KT446065 | Streptomyces anulatus NRRL B2000 | 59.05 | Desertas | H11 | DQ026637.1 |
| PTM-46 | KT446118 | Streptomyces rubrogriseus LMG 20318 | 1.32 | Desertas | H11 | AJ781373.1 |
| PTM-63 | KT446126 | Streptomyces violaceochromogenes NBRC 13100 | 13.99 | Desertas | H11 | AB184312.1 |
| PTM-81 | KT446195 | Streptomyces aculeolatus MAR4 | 19.55 | Madeira | H1 | KP869061.1 |
| PTM-85 | KT446127 | Streptomyces violaceochromogenes NBRC 13100 | 32.05 | Desertas | H11 | AB184312.1 |
| PTM-99 | KT446218 | Salinispora arenicola MAR1 | 4.94 | Desertas | H11 | KJ685387.1 |
| PTM-105 | KT446303 | Micromonospora aurantiaca ATCC 27029 | 7.90 | Porto Santo | H11 | HG526643.1 |
| PTM-106 | KT446085 | Streptomyces anulatus NRRL B2000 | 9.98 | Desertas | H11 | DQ026637.1 |
| PTM-126 | KT446128 | Streptomyces violaceochromogenes NBRC 13100 | 18.02 | Desertas | H11 | AB184312.1 |
| PTM-128 | KT446196 | Micromonospora aurantiaca ATCC 27029 | 40.22 | Madeira | H4 | HG526643.1 |
| PTM-304 | KT446075 | Streptomyces anulatus NRRL B2000 | 0.65 | Desertas | H11 | DQ026637.1 |
| PTM-366 | KT446072 | Streptomyces anulatus NRRL B2000 | 24.98 | Desertas | H11 | DQ026637.1 |
| PTM-392 | KT446070 | Streptomyces anulatus NRRL B2000 | 8.50 | Desertas | H11 | DQ026637.1 |
| 5-Fluorouracil | NA | 0.19 | NA | NA | NA | |
| Oxaliplatin | NA | 0.18 | NA | NA | NA |
a
Cell viability was assessed using the MTS assay; NA, Not applicable.