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. 2016 Oct 7;6:122. doi: 10.3389/fcimb.2016.00122

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Copyright © 2016 Santucci, Bouzid, Smichi, Poncin, Kremer, De Chastellier, Drancourt and Canaan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the adipocyte model. (A) The differentiation procedure of precursor cells, such as mesenchymal stem cells (MSCs) or 3T3-L1, into mature adipocytes includes treatment with 3-isobutyl-1-methylxanthine (IBMX), dexamethasone (DEX), and insulin (INS). (B) Mature adipocytes, filled with LB, are infected with pathogenic mycobacteria which are phagocytosed after binding to scavenger receptors (Neyrolles et al., 2006). Ultimately, mycobacteria accumulate lipids in the form of ILI.