The average information content of the TSS regions of human, mouse, and E. coli as a function of the block size. Histograms shown in A1, B1, and C1 (top row) represent the information content determined by using the neighbor-independent matrix. Similarly, A2, B2, and C2 (bottom row) represent the information content by using the neighbor-dependent matrix. In each graph the bars represent the information content for blocks of 5 (–2 to +3), 11 (–5 to +6), and 15 (–7 to +8) nt, respectively. The positions are with reference to TSS that represents +1. The error bars in A2, B2, and C2 are too small to be seen in the plot.