Fig. 4.

Molecular modeling of Plexin B3 protein. A. Molecular modeling of the sema domain of Plexin B3 was performed using the web-based homology modeling server CPHmodels 2.0 utilizing Met receptor as a template. All modeling was carried out using Swiss Model and was viewed using Swiss-PdbViewer. Note the structure of the sema domain of Met (a) and Plexin B3 (b). B. The structure of the sema domain from Plexin B3 overlapped with that of Met receptor. C. The amino acids corresponding to the binding peptide NAFTPDY are conserved and surface exposed in Plexin B3 similar to Met receptor.