Table 1.
Basic cellular machinery for the RNA world and the CB world
| Cellular machinery | Phase | World and function | Substrate * |
||
|---|---|---|---|---|---|
| R | P | D | |||
| Editosome | I | The RNA world I: RNA synthesis and editing | + | ||
| Spliceosome | I | The RNA world I: RNA splicing | + | ||
| Translatosome | II | The RNA world II: RNA–peptide and protein synthesis | + | + | |
| Reverse-transcriptosome | III | The CB world: RNA-based DNA synthesis | + | + | |
| Transcriptosome | III | The CB world: DNA-based RNA synthesis | + | + | |
| Replisome | III | The CB world: DNA replication | + | + | |
| Repairosome | III | The CB world: DNA repair | + | + | |
*
R, P, and D stand for RNA, protein, and DNA, respectively. The “+” signs indicate the presence of a particular molecular mechanism and its corresponding substrates.