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. 2012 Jun 8;10(2):82–93. doi: 10.1016/j.gpb.2012.05.007

Figure 1.

Figure 1

H3K4me3 and H3K27me3 modifications around TSS Profiles of H3K4me3 modifications across the TSS were shown for high, medium, low, ambiguous, and silent expression genes in cerebrum (A) and testis (B). Profiles of H3K27me3 modifications across the TSS were shown for high, medium, low, ambiguous, and silent expression genes in cerebrum (C) and testis (D). The significantly expressed genes (ncerebrum = 16,992 and ntesits = 17,400) were equally classified into three groups (high, medium and low) according to gene expression level. To ensure a clean separation between low and silent expression genes, we defined a group of ambiguous expression genes (ncerebrum = 1905 and ntesits = 2511). These genes had rmRNA-seq reads detected, but their expression level is lower than background. This group of genes displayed properties consistent with being a mixture of low and silent expression. Silent genes (ncerebrum = 2318 and ntesits = 1304) were defined as genes with no reads obtained. Shown in (E) and (F) were profiles of H3K4me3 and H3K27me3 across the TSS in ESCs, respectively.