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. 2012 Jun 8;10(2):82–93. doi: 10.1016/j.gpb.2012.05.007

Figure 2.

Figure 2

Cerebrum or testis specific chromatin marking In this figure, we set the maximum coverage for modification and expression as 10 and 20, respectively. In addition, the range of horizontal axes is from 1 kb upstream of the gene to 1 kb downstream of the gene in chromosome. We also displayed the SICER defined enrichment intervals for H3K4me3 and H3K27me3 under horizontal axes. (A) The gene, Rims3, involved in regulating nerve signal transduction, is marked by H3K4me3 at promoter region in cerebrum, but not in testis. Moreover, H3K4me3 modification is well associated with gene expression with higher expression level in cerebrum than in testis. (B) The gene, Prm1, related to spermatogenesis, shows testis-specific H3K4me3 modification and expression. (C) The gene, Orm2, involved in immune suppression, shows cerebrum-specific H3K27me3 modification. (D) The gene, Pcdhb10, involved in cell-cell connection shows testis-specific H3K27me3 modification and expression.