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. 2012 Jun 8;10(2):82–93. doi: 10.1016/j.gpb.2012.05.007

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© 2012 Beijing Institute of Genomics, Chinese Academy of Sciences and Genetics Society of China. Published by Elsevier Ltd and Science Press. All rights reserved.

This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Expression pattern of bivalent chromatin domains in cerebrum and testis (A) Box plot showing 25th, 50th, and 75th percentile expression levels in cerebrum (left), testis (middle) and ESC (right) for genes associated with no histone methylation (none, black), H3K4me3 only (K4, red), H3K27me3 only (K27, green), stronger H3K4me3 in the bivalent domain (K4 > K27, blue) and stronger H3K27me3 in the bivalent domain (K27 > K4, purple). Whiskers show 1.5 times of 25th and 75th percentile expression. The gene expression level is measured by RPKM values (Y axis). (B) Cumulative distribution of expression levels for genes associated with no histone methylation (none, black), H3K4me3 only (K4, red), H3K27me3 only (K27, green), stronger H3K4me3 in the bivalent domain (K4 > K27, blue) and stronger H3K27me3 in the bivalent domain (K27 > K4, purple). (C) The distribution of expression levels for genes associated with no histone methylation (none, black), H3K4me3 only (K4, red), H3K27me3 only (K27, green), stronger H3K4me3 in the bivalent domain (K4 > K27, blue) and stronger H3K27me3 in the bivalent domain (K27 > K4, purple).