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The relationship between ROS, MEK1/2, p38 MAPK and Nrf2. Neurons were pretreated with ROS scavenger (NAC, 5 mM), MEK1/2 inhibitor (U0126, 10 μM) or p38 MAPK inhibitor (SB203580, 10 μM) 30 min before HBO exposure. The phosphorylation of MEK1/2 (A, D), p38 MAPK (B, E), and the nucleus translocation of Nrf2 (C, F) were determined by western blot. Significance compared with Air group, **p<0.01; significance compared with HBO group, ††p<0.01.
