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. 2016 Oct 7;3(5):ENEURO.0089-16.2016. doi: 10.1523/ENEURO.0089-16.2016

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Copyright © 2016 Vidal et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 3. — At P23, dendritic spine density on L2/3 pyramidal cells in PirB^−/− visual cortex is similar to that of PirB^+/+. A, Fluorescent micrograph at P23, an age near the onset of spine pruning, showing an isolated L2/3 pyramidal neuron electroporated with GFP.Cre at E15.5. B, High-magnification, maximum-intensity projection of boxed area in A showing spines on basal dendrites of GFP⁺;Cre⁺ L2/3 neuron. C, Basal dendrite spine density is higher in PirB^+/+ neurons at P23 than in PirB^+/+ neurons at P30 (P30 data indicated by dotted line; data from Fig. 2H); spine density from P23 PirB^+/+ is not different from PirB^fl/fl or PirB^−/− neurons (P23 PirB^+/+: 12.66 ± 1.5, n = 6 cells, 3 mice; P23 PirB^fl/fl: 14.43 ± 0.9, n = 7 cells, 5 mice; P23 PirB^−/−: 13.39 ± 1.1, n = 8 cells, 4 mice; P23 PirB^+/+vs P23 PirB^−/−, p = 1.000^g; P23 PirB^+/+ vs P23 PirB^fl/fl, p = 0.924^g; P23 PirB^fl/fl vs PirB^−/−, p = 1.000^g, one-way ANOVA with post hoc Bonferroni’s multiple comparisons; P23 PirB^+/+ vs P30 PirB^+/+, p = 0.004^g; P23 PirB^fl/fl vs P30 PirB^fl/fl, p = 0.19^g; P23 PirB^−/− vs P30 PirB^−/−, p = 1.00^g, one-way ANOVA with post hoc Bonferroni’s multiple comparisons). D, Cumulative histogram (by cell) of data presented in C. Scale bars: A, 50 μm; B, 5 μm.