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. 2016 Oct 7;6:34857. doi: 10.1038/srep34857

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Multivariate regression was used to investigate the joint associations between all metabolites and mean DNA methylation, adjusting for confounders: maternal smoking, maternal prepregnancy BMI, delivery mode, and infant birth weight. M1 and M2 metabolites that were significantly associated with global or candidate gene loci are plotted in the heatmap. Negative associations are denoted in blue, positive associations in red.