Figure 2. Effects of EE and AE on pain behaviours induced by CCI.

(a) Sensitivity to a noxious mechanical stimulus as measured by the Paw-pressure test. (b) Pain threshold to a non-noxious mechanical stimulus as measured by the Von Frey test. (c) Pain assessed by hind limb weight bearing alterations using an Incapacitance test; data are expressed as the difference between the weight applied on the limb contralateral to the injury and the weight applied on the ipsilateral limb. Behavioural tests were performed 14 days after operation, 24h after the last treatment. Vegetal extracts were administered p.o.; control animals were subjected to sham surgery and treated with vehicle. Treatments were performed daily starting on the day of surgery. Each value represents the mean ± SEM of 10 rats per group, performed in 2 different experimental sets. ^{^^^}P < 0.001 versus sham + vehicle; *P < 0.05, **P < 0.01 and ***P < 0.001 versus CCI + vehicle.