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. Author manuscript; available in PMC: 2016 Oct 7.
Published in final edited form as: Endocrinol Metab Clin North Am. 2014 Sep;43(3):665–684. doi: 10.1016/j.ecl.2014.06.003

Fig. 1.

Fig. 1

PIs may modify lipoprotein metabolism through multiple mechanisms. PIs directly stimulate the biosynthesis of triglycerides in hepatic cells and may also directly modify the metabolism of lipoproteins by binding to cellular receptors, reducing lipolysis and by regulating expression of key genes involved in the regulation of metabolic pathways in adipocytes and hepatocytes. CRABP-1, cellular retinoic acid-binding protein 1; LRP, low-density lipoprotein receptor protein; PPARs, peroxisome proliferator-activated receptors; SREBPs, sterol regulatory element-binding proteins.